Baadhista qaab-dhismeedka daroogada iyo qiimaynta joogtada ah

Korjoogteynta khadka tooska ah waxay bixisaa natiijooyin degdeg ah oo loogu talagalay tijaabinta kristanta, xogta joogtada ah waxay kicisaa hababka falcelinta iyo dhibcaha dhamaadka, bixinta hagaajinta, tilmaamaha.

Noocyada kala duwan ee crystals ee isla dawada la mid ah ayaa laga yaabaa inay muujiyaan kala duwanaansho weyn oo muuqaal ah, milmayn, barta dhalaalka, heerka kala dirida, bioavailability, iwm.Sidaa darteed, waxaa lagama maarmaan ah in la xaqiijiyo joogitaanka qaabka crystal bartilmaameedka inta lagu guda jiro isku-darka daroogada iyo hababka qaabeynta.

Inta lagu jiro habka horumarinta daroogada cusub, waxaa lagama maarmaan ah in la kormeero waqtiga dhabta ah ee ka kooban wajiga crystalline ee daroogada ee xalka falcelinta falcelinta.Tan waxa loo sameeyaa si kor loogu qaado habka iyo in la hubiyo in dawada bartilmaameedkeeda wejiga crystalline la mideeyey.Raman spectroscopy waxaa loo isticmaali karaa la socodka goobta, bixinta falanqaynta waqtiga-dhabta ah ee ka kooban wajiga crystalline falcelinta falgalka daroogada, gaar ahaan ku haboon falanqaynta dhamaystiran ee polymorphic iyo amorphous API-ka kooban nidaamyada.

Shabakadda Raman ee khadka tooska ah ayaa sahlaysa baadhista wajiga crystal ee xaaladaha falcelinta ee kala duwan, sida lagu muujiyey tijaabada shirkad dawooyin ahNatiijooyinka waxa la xaqiijiyay in ay la jaanqaadaan walaxda dawooyinka ee firfircoon, taas oo muujinaysa cilmi-baadhis guul leh.Xaddidaadihii hore ee isticmaalka XRD iyo qalabka kale ee shaybaadhka ayaa horseeday caqabadaha xogta iyo wareegyada horumarka oo la fidiyey.Kiis kale ayaa iftiimiyay kala-duwanaanshaha waqtiga-dhabta ah ee guusha leh ee isbeddelka wejiga kristal ee lix hab oo kala duwan, oo siinaya aragtiyo degdeg ah natiijooyinka badeecada.